venofer dosing calculator

20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Last updated on Jun 1, 2022. [. Due Date form Ultrasound Report. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Minor/Significance Unknown. Applies only to oral form of both agents. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. (3) Known hypersensitivity to Venofer. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Ferric gluconate: 12.5 mg/mL. Modify Therapy/Monitor Closely. iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. an automated flowchart approach. Applies only to oral form of both agents. Fulminant symptoms may include general paleness, confusion or episodes of passing out. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Applies only to oral form of both agents. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Avoid or Use Alternate Drug. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. For additional Safety Information, please see Full Prescribing Information. Patients measured hemoglobin can be input in g/dL or mmol/L. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Shirley, NY: American Regent, Inc.; 9/2020. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Oral and parenteral products - see background option for oral products. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. Pediatric Patients (2 Years of Age and Older). -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] iron sucrose decreases levels of deferiprone by enhancing GI absorption. Applies only to oral form of both agents. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. ANNA J. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Minor/Significance Unknown. Drug class: Iron products. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Before using, check this product visually for particles or discoloration. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Information last revised December 2022. All Rights Reserved. Minor/Significance Unknown. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Use Caution/Monitor. Modify Therapy/Monitor Closely. Minor/Significance Unknown. You can further save the PDF or print it. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Venofer must only be administered intravenously either by slow injection or by infusion. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. May increase risk of hypotension. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. This information does not assure that this product is safe, effective, or appropriate for you. Applies only to oral form of both agents. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Am J HealthSyst Pharm 2006;63:731735. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. We'll do this entirely for free, as long as the calculator has applications for women's health. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Applies only to oral form of both agents. Pain, swelling, or redness at the injection site may occur. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Applies only to oral form of both agents. Do Not Copy, Distribute or otherwise Disseminate without express permission. Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. Below the form there are further instructions on how to use the calculator. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? You may need extra iron because of blood loss during kidney dialysis. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Modify Therapy/Monitor Closely. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Methods. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Intravenous iron sucrose: establishing a safe dose. Chandler G, Harchowel J, Macdougall I. Avoid or Use Alternate Drug. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Applies only to oral form of both agents. Interaction only with oral iron administration. Separate by 2 hr. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. All Rights Reserved. Reactions have occurred following the first dose or subsequent doses of Venofer. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Anemia; 2015: 763576. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Adding plans allows you to compare formulary status to other drugs in the same class. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Use Caution/Monitor. Each mL contains 20 mg of elemental iron. Applies only to oral form of both agents. This may be helped by giving the medication more slowly or at a lower dose. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Applies only to oral form of both agents. This website is intended for use by US healthcare professionals only. Avoid or Use Alternate Drug. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Separate by at least 4 hours. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Each costs about $0.46 to $0.55 per mg of iron. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Applies only to oral form of both agents. By clicking send, you acknowledge that you have permission to email the recipient with this information. For liquid medications, also enter the value of the Medicine Concentration and choose . Applies only to oral form of both agents. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Applies only to oral form of both agents. Medically reviewed by Drugs.com. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Minor/Significance Unknown. This information is not individual medical advice and does not substitute for the advice of your health care professional. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Applies only to oral form of both agents. The elemental iron product used is Iron sucrose 20 mg/mL. Applies only to oral form of both agents. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Applies only to oral form of both agents. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Administer Venofer only intravenously by slow injection or by infusion. Avoid or Use Alternate Drug. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. Fatal reactions have followed the test dose of iron dextran injection. Use Caution/Monitor. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. commonly, these are "preferred" (on formulary) brand drugs. Applies only to oral form of both agents. Avoid or Use Alternate Drug.

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